Private Schools in East Prairie, Missouri

St. Mary's School is a highly-regarded Catholic private school located in nearby Sikeston, serving students from East Prairie and surrounding communities. The school offers comprehensive education from pre-kindergarten through 8th grade with a strong emphasis on faith-based learning combined with rigorous academics. Features include modern classrooms, dedicated faculty with an average of 15+ years teaching experience, robust STEM programs, music and arts education, and competitive athletic programs. The school maintains small class sizes with a student-teacher ratio of 15:1, ensuring personalized attention and strong academic outcomes.

Located in nearby Charleston, St. Henry Catholic School serves families throughout Mississippi County including East Prairie. This established private institution offers education from preschool through 8th grade with a classical education approach that emphasizes critical thinking, moral development, and academic excellence. The school features updated technology labs, comprehensive religious education, competitive sports programs, and extensive extracurricular activities. With a strong community reputation and consistent high parent satisfaction ratings, St. Henry provides a nurturing environment with dedicated teachers and a focus on developing well-rounded students.

Notre Dame Regional High School is a premier Catholic high school located in Cape Girardeau that serves students from East Prairie and throughout Southeast Missouri. As the region's leading private secondary institution, Notre Dame offers a comprehensive college-preparatory curriculum with numerous Advanced Placement courses, competitive athletic programs, and extensive extracurricular opportunities. The campus features state-of-the-art facilities including modern science labs, performing arts center, athletic complex, and technology-enhanced classrooms. With a 98% college acceptance rate and strong academic reputation, Notre Dame prepares students for higher education success while emphasizing character development and community service.